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A 1120

Catalog #: 3793
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3793/10
3793/50
A 1120 | CAS No. 1152782-19-8 | Miscellaneous Compounds
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Description: High affinity retinol-binding protein 4 (RBP4) ligand

Chemical Name: 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

A 1120 is a high affinity retinol-binding protein 4 (RBP4) ligand (Ki = 8.3 nM); non-retinoid. Selective against a range of different cellular targets. As efficacious as fenretinide (Cat. No. 1396) in the reduction of serum RBP4 and retinol. Displaces transthyretin (TTR) from RBP4-TTR complexes.

Technical Data

M.Wt:
392.37
Formula:
C20H19F3N2O3
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
1152782-19-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration
    M Du, E Phelps, MJ Balangue, A Dockins, G Moiseyev, Y Shin, S Kane, L Otalora, JX Ma, R Farjo, KM Farjo
    Invest. Ophthalmol. Vis. Sci., 2017;58(10):4095-4103.
  2. All-trans retinoic acid lowers serum retinol-binding protein 4 concentrations and increases Ins sensitivity in diabetic mice.
    Manolescu et al.
    J.Nutr., 2009;140:311
  3. Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo.
    Motani et al.
    J.Biol.Chem., 2009;284:7673

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Citation for A 1120

The citations listed below are publications that use Tocris products. Selected citations for A 1120 include:

1 Citation: Showing 1 - 1

  1. Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration.
    Authors: Du Et al.
    Invest Ophthalmol Vis Sci  2017;58:4375?4383

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