Home / Two-P Potassium Channels Blockers / A 1899

A 1899

Catalog #: 6972 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6972/25
6972/5
A 1899 | CAS No. 498577-46-1 | Two-P Potassium Channels Blockers
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Description: Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker

Chemical Name: N-[(2,4-Difluorophenyl)methyl]-2'-[[[2-(4-methoxyphenyl)acetyl]amino]methyl][1,1'-biphenyl]-2-carboxamide

Purity: ≥98%

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Biological Activity

A 1899 is a potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) channel blocker (IC50 values are 7 nM and 70 nM for human TASK-1 and TASK-3 expressed in CHO cells, respectively). Displays >12.5-fold selectivity for TASK-1 and TASK-3 over other K+ channels (IC50 = 0.9 μM for K2P18.1/TRESK and >2 μM for all other channels tested). Binds within open channel pore.

Technical Data

M.Wt:
500.55
Formula:
C30H26F2N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
498577-46-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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