A 419259 trihydrochloride
Chemical Name: 7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-Pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride
Purity: ≥98%
Biological Activity
A 419259 trihydrochloride is a potent Hck inhibitor (IC50 = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including CD34+. Also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitro and in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo.
Saito et al.
Sci.Transl.Med., 2013;5 -
Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis.
Wilson et al.
Oncogene, 2002;21:8075 -
An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad spectrum Src family kinase inhibitor A-419259.
Pene-Dumitrescu et al.
Oncogene, 2008;27:7055
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Citations for A 419259 trihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for A 419259 trihydrochloride include:
6 Citations: Showing 1 - 6
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Recapitulating porcine cardiac development in vitro: from expanded potential stem cell to embryo culture models.
Authors: Alessandra Et al.
Front Cell Dev Biol 2023;11:1111684
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The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells.
Authors: Wendy Et al.
Elife 2022;11
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Timely stimulation of early embryo promotes the acquisition of pluripotency.
Authors: Fengying Et al.
Cytometry A 2022;101:682-691
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Protocol for the generation of blastocyst-like structures from mouse extended pluripotent stem cells.
Authors: Juan Carlos Et al.
STAR Protoc 2021;2:100745
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Establishment of porcine and human expanded potential stem cells.
Authors: Gao Et al.
Nat Cell Bio 2019;21:687
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Generation of blastocyst-like structures from mouse embryonic and adult cell cultures.
Authors: Li Et al.
Cell 2019;179:687
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