Home / CCK1 Receptor Agonists / A-71623

A-71623

Catalog #: 2411 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2411/1
A-71623
1 Image
Description: Potent and selective CCK1 agonist; suppresses feeding

Purity: ≥95%

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Biological Activity

A-71623 is a potent CCK1 agonist (IC50 = 3.7 nM) with 1200-fold selectivity over the CCK2 receptor. Suppresses food intake following central or peripheral administration.

Technical Data

M.Wt:
840.97
Formula:
C44H56N8O9
Sequence:
WKDF

(Modifications: Trp-1 = Boc-Trp, Lys-2 = Lys(Tac), Phe-4 = N-methyl-Phe & C-terminal amide)

Solubility:
Soluble to 1 mg/ml in 20mM PBS buffer
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
130408-77-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey.
    Asin et al.
    Pharmacol.Biochem.Behav., 1992;42:699
  2. Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists.
    DeNinno et al.
    J.Med.Chem., 1990;33:2951
  3. Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors.
    Lin et al.
    Mol.Pharmacol., 1990;39:346

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