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A 844606

Catalog #: 4477 Datasheet / COA / SDS

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4477 has been discontinued.
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A 844606 | CAS No. 861119-08-6 | Nicotinic (a7) Receptor Agonists
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Description: Selective α7 nAChR partial agonist

Chemical Name: 2-(Hexahydro-5-methylpyrrolo[3,4-c]pyrrol-2(1H)-yl)-9H-xanthen-9-one

Purity: ≥99%

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Biological Activity

A 844606 is a selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist (EC50 values are 1.4 and 2.2 μM at human and rat receptors respectively). Displays no measurable effect on α4β2 nAChRs. Stimulates α7 nAChR-induced ERK1/2 phosphorylation in PC12 cells.

Technical Data

M.Wt:
320.38
Formula:
C20H20N2O2
Solubility:
Soluble to 5 mM in ethanol with gentle warming
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
861119-08-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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