A 967079
Chemical Name: (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime
Purity: ≥98%
Biological Activity
A 967079 (also known as A-079) is a selective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively) that displays 1000-fold selectivity for TRPA1 over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes and G-protein-coupled receptors. A 967079 exhibits analgesic effects in a rat osteoarthritic pain model.External Portal Information
The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of A 967079 (A-079) is reviewed.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats.
McGaraughty et al.
Mol.Pain, 2010;6:14 -
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.
Chen et al.
Pain, 2011;152:1165
Product Datasheets
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Citations for A 967079
The citations listed below are publications that use Tocris products. Selected citations for A 967079 include:
12 Citations: Showing 1 - 10
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Anti-Inflammatory Effects of Cannabigerol in Rheumatoid Arthritis Synovial Fibroblasts and Peripheral Blood Mononuclear Cell Cultures Are Partly Mediated by TRPA1.
Authors: Georg Et al.
Int J Mol Sci 2023;24
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The Role of Transient Receptor Potential A1 and G Protein-Coupled Receptor 39 in Zinc-Mediated Acute and Chronic Itch in Mice.
Authors: Tong Et al.
Front Mol Neurosci 2022;14:768731
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Irritant-evoked activation and calcium modulation of the TRPA1 receptor.
Authors: Zhao Et al.
Nature 2020;585:141
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Spinal GRPR and NPRA Contribute to Chronic Itch in a Murine Model of Allergic Contact Dermatitis.
Authors: Xueting Et al.
J Invest Dermatol 2020;140:1856-1866.e7
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Cannabidiol activation of vagal afferent neurons requires TRPA1.
Authors: James H Et al.
J Neurophysiol 2020;124:1388-1398
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Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts.
Authors: Georg Et al.
Cell Death Dis 2020;11:714
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The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes.
Authors: Cheng Et al.
Theranostics 2019;9:4287
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A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery.
Authors: Ko Et al.
Sci Rep 2019;9:2430
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ROS/TRPA1/CGRP signaling mediates cortical spreading depression.
Authors: Jiang Et al.
J Headache Pain 2019;20:25
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Ethyl Vanillin Activates TRPA1.
Authors: Wu Et al.
J Pharmacol Exp Ther 2017;362:368
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Structure of the TRPA1 ion channel suggests regulatory mechanisms.
Authors: Paulsen Et al.
Nature 2015;520:511
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Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets.
Authors: Ganley Et al.
Mol Brain 2015;35:7626
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