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A12B4C3

Catalog #: 5097 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5097/10
5097/50
A12B4C3 | CAS No. 1005129-80-5 | Other Kinase Inhibitors
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Description: Potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor

Chemical Name: 4a,7a-Dihydro-2-(1-hydroxyundecyl)-1-[(4-nitrophenyl)amino]-6-phenyl-1H-pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione

Purity: ≥98%

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Biological Activity

A12B4C3 is a potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor (IC50 = 60 nM). Displays no effect on calcineurin, protein PP-1 or APTX. Interrupts DNA repair and enhances radiosensitivity of human A549 lung carcinoma and MDA-MB-231 cells.

Technical Data

M.Wt:
534.65
Formula:
C30H38N4O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1005129-80-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of a Small Molecule Inhibitor of the Human DNA Repair Enzyme Polynucleotide Kinase/Phosphatase.
    Freschauf GK, Karimi-Busheri F, Ulaczyk-Lesanko A et al.
    Cancer Res
  2. Mechanism of Action of an Imidopiperidine Inhibitor of Human Polynucleotide Kinase/Phosphatase.
    Freschauf GK, Mani RS, Mereniuk TR et al.
    JBC
  3. DNA end processing by polynucleotide kinase/phosphatase.
    Schellenberg et al.
    Proc.Natl.Acad.Sci.U.S.A., 2011;108:20855

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