AA 29504
Chemical Name: N1-Ethoxycarbonyl-N4-[(2,4,6-trimethylpheny)lmethyl]-1,2,4-triaminobenzene
Purity: ≥98%
Biological Activity
AA 29504 is a positive allosteric modulator of GABAA receptors. Modulates both α4β3δ-containing extrasynaptic receptors and α1β3γ2S-containing receptors in Xenopus oocytes, displaying a stronger modulatory effect at the former. Reduces motor coordination and exhibits anxiolytic effects in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pharmacological characterization of a novel positive modulator at α4β3δ-containing extrasynaptic GABAA receptors.
Hoestgaard-Jensen et al.
Neuropharmacology, 2010;58:702 -
Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors.
Olander et al.
Biochem. Pharmacol., 2018;
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Citation for AA 29504
The citations listed below are publications that use Tocris products. Selected citations for AA 29504 include:
1 Citation: Showing 1 - 1
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Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors.
Authors: Olander Et al.
Biochem.Pharmacol. 2018;150:305
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