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AAQ chloride

Catalog #: 5462
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5462/50
5462/10
AAQ chloride | Voltage-gated Potassium Channel Modulators
1 Image
Description: Photoswitchable Kv channel blocker

Chemical Name: N,N,N-Triethyl-2-oxo-2-[[4-[2-[4-[(1-oxo-2-propen-1-yl)amino]phenyl]diazenyl]phenylamino]ethanaminium chloride

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

AAQ chloride is a photoswitchable Kv channel blocker (IC50 values are 2 and 64 μM at 500 nm and 380 nm respectively). Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Exhibits minimal activity at Nav1.2 and L-type Ca2+ channels. Stimulates action potential firing of hippocampal neurons in vitro at 500 nm and restores visual responsiveness in blind mice at 380 nm.

Technical Data

M.Wt:
443.97
Formula:
C23H30ClN5O2
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Photoswitch Biosciences, Inc.

Background References

  1. Photochromic blockers of voltage-gated potassium channels.
    Banghart MR et al.
    Angew.Chem.Int.Ed., 2009;48:9097
  2. Photochemical control of endogenous ion channels and cellular excitability.
    Fortin et al.
    Nat.Methods, 2008;5:331
  3. Photochemical restoration of visual responses in blind mice.
    Polosukhina et al.
    Neuron, 2012;75:271

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for AAQ chloride

The citations listed below are publications that use Tocris products. Selected citations for AAQ chloride include:

1 Citation: Showing 1 - 1

  1. Development of a quaternary ammonium photoswitchable antagonist of NMDA receptors.
    Authors: Nikolaev Et al.
    Eur J Pharmacol.  2022;938:175448

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