Abiraterone acetate

Catalog #: 6520 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
6520/5
6520/25

Abiraterone acetate | CAS No. 154229-18-2 | Cytochrome P450 Inhibitors

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Description: Potent CYP17A1 inhibitor

Chemical Name: (3β)-17-(3-Pyridinyl)androsta-5,16-dien-3-yl acetate

Purity: ≥98%

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Biological Activity

Abiraterone acetate is a potent CYP17A1 inhibitor (IC₅₀ values are 17 nM and 18 nM for 17,20-lyase activity and 17α-hydroxylase activity, respectively). Inhibits intratumor androgen synthesis in prostate cancer.

Technical Data

M.Wt:

391.55

Formula:

C₂₆H₃₃NO₂

Solubility:

Soluble to 20 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

154229-18-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Novel steroidal inhibitors of human cytochrome P450_17α (l7α-Hydroxylase-C_l7,20-lyase): potential agents for the treatment of prostatic cancer.
Potter et al.
J.Med.Chem., 1995;38:2463
Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase).
Barrie et al.
J.Steroid Biochem.Mol.Biol., 1994;50:267

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

⚠ WARNING: This product can expose you to chemicals including Abiraterone acetate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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