AC 55649
Chemical Name: 4'-Octyl-[1,1'-biphenyl]-4-carboxylic acid
Purity: ≥99%
Biological Activity
AC 55649 is a potent, isoform-selective RARβ2 receptor agonist (pEC50 values are 6.9, 5.7 and 5.6 at RARβ2, RARβ1 and RARα respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations
JH Lee, SI Protze, Z Laksman, PH Backx, GM Keller
Cell Stem Cell, 2017;21(2):179-194.e4. -
Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist.
Lund et al.
J.Med.Chem., 2005;48:7517 -
Design, synthesis, and structure-activity analysis of isoform selective retinoic acid receptor ligands.
Lund et al.
J.Med.Chem., 2009;52:1540
Product Datasheets
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Citations for AC 55649
The citations listed below are publications that use Tocris products. Selected citations for AC 55649 include:
5 Citations: Showing 1 - 5
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Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells.
Authors: Shrestha Et al.
Nat Commun 2017;8:150
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Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations.
Authors: Lee Et al.
Cell Stem Cell 2017;21:179
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Retinoic acid receptor gamma impacts cellular adhesion, Alpha5 Beta1 integrin expression and proliferation in K562 cells.
Authors: Kelley
PLoS One 2017;12(5):e0178116
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Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells.
Authors: Kang Et al.
Front Behav Neurosci 2011;4:66
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A comparison of the roles of peroxisome proliferator-activated receptor and retinoic acid receptor on CYP26 regulation.
Authors: Tay Et al.
Mol Pharmacol 2010;77:218
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