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Ac-FLTD-CMK

Catalog #: 7242 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7242/1
Ac-FLTD-CMK
1 Image
Description: Potent and selective inhibitor of caspases 1, 5 and 4

Purity: ≥95%

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Biological Activity

Ac-FLTD-CMK is a potent and selective inhibitor of caspases 1, 5 and 4 (IC50 values = 46.7 nM, 0.33 μM, 1.49 μM, respectively), and inhibits murine caspase-11 at 10 μM. Ac-FLTD-CMK inhibits cleavage of gasdermin D by caspases, suppresses pyroptosis and reduces IL-1β release in macrophages.

Technical Data

M.Wt:
569.05
Formula:
C26H37ClN4O8
Sequence:
FLTD

(Modifications: Phe-1 = Ac-Phe, Asp-4 = Asp-CMK)

Solubility:
Soluble to 1 mg/ml in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2376255-48-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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