Ac-RYYRIK-NH₂

Name: Ac-RYYRIK-NH 2
Brand: Tocris Bioscience
SKU: 1239
Price: 172 USD

Catalog #: 1239 Datasheet / COA / SDS

Discontinued Product

1239 has been discontinued.

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Description: High affinity NOP ligand

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Biological Activity

Ac-RYYRIK-NH₂ is a high affinity ligand for the NOP site (K_i = 1.5 nM). Antagonizes nociceptin-stimulated GTP binding in rat brain and the chronotropic effect of nociceptin on rat cardiomyocytes. However, displays potent agonist properties in vivo, inhibiting locomotor activity in mice.

Technical Data

M.Wt:

939.12

Formula:

C₄₄H₇₀N₁₄O₉

Sequence:

RYYRIK

(Modifications: Arg-1 = N-terminal Ac, Lys-6 = C-terminal amide)

Storage:

Desiccate at -20°C

CAS No:

200959-48-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Antagonism by acetyl-RYYRIK-NH₂ of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ.
Berger et al.
Br.J.Pharmacol., 1999;126:555
Acetyl-RYYRIK-NH₂, a nociceptin/orphanin FQ (noc/OFQ) receptor ligand, exhibits properties of an antagonist and agonist as well.
Berger et al.
Regul.Pept., 1999;80:122
Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL₁.
Dooley et al.
J.Pharmacol.Exp.Ther., 1997;283:735

Product Datasheets

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service

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Ac-RYYRIK-NH2