Ac2-12
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Description: Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation
Biological Activity
Ac2-12 is an annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, and promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo.Technical Data
M.Wt:
1351.58
Formula:
C63H94N14O17S
Sequence:
AMVSEFLKQAW
(Modifications: Ala-1 = N-terminal Ac)
Solubility:
Soluble to 1 mg/ml in 20% acetonitrile / water
Storage:
Desiccate at -20°C
CAS No:
256447-08-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1
Lim et al.
Proc.Natl.Acad.Sci.U.S.A., 1998;95:14535 -
Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics.
Perretti et al.
Am.J.Pathol., 2001;158:1969
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