ACPT-I
Chemical Name: (1S,3R,4S)-1-Aminocyclopentane-1,3,4-tricarboxylic acid
Biological Activity
ACPT-I is a agonist for group III mGlu receptors (EC50 values are 7.2 and 8.2 μM for mGlu4a and mGlu8 respectively). Anticonvulsant in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes.
Acher et al.
J.Med.Chem., 1997;40:3119 -
Anticonvulsant activity of a mGlu4α receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid.
Chapman et al.
Eur.J.Pharmacol., 2001;424:107 -
Pharmacological characterization of the rat metabotropic glutamate receptor 8a revealed strong similarities and slight differences with the type 4a receptor.
De Colle et al.
Eur.J.Pharmacol., 2000;394:17
Product Datasheets
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Citation for ACPT-I
The citations listed below are publications that use Tocris products. Selected citations for ACPT-I include:
1 Citation: Showing 1 - 1
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Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo.
Authors: Domin Et al.
Proc Natl Acad Sci U S A 2014;26:99
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