Acyclovir
Chemical Name: 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one
Purity: ≥99%
Biological Activity
Acyclovir is an antiviral agent, active against herpes simplex viruses HSV-1 and HSV-2 (EC50 values are 0.85 and 0.86 μM respectively). Interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate. Induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy.
Hayashi et al.
J.Gene.Med., 2006;8:1056 -
Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus.
Suzuki et al.
Antiviral Res., 2006;72:157 -
Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine.
Elion et al.
Proc.Natl.Acad.Sci.USA., 1977;74:5716
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