Adenosine 5'-(α,β-methylene)diphosphate sodium salt

Biological Activity

Adenosine 5'-(α,β-methylene)diphosphate sodium salt is an ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses the doxorubicin-resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
   DK Chiu, AP Tse, IM Xu, J Di Cui, RK Lai, LL Li, HY Koh, FH Tsang, LL Wei, CM Wong, IO Ng, CC Wong
   Nat Commun, 2017;8(1):517.
2. IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier.
   Niemelä et al.
   Eur.J.Immunol., 2008;38:2718
3. Purinergic control of vascular tone in the retina.
   Kur et al.
   J.Physiol., 2014;592:491
4. Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance.
   Ujházy et al.
   Int.J.Cancer., 1996;68:493
5. Asthmatic augmentation of airway vagal activity involves decreased central expression and activity of CD73 in rats.
   Chen et al.
   ACS Chem.Neurosci., 2019;10:2809

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