(±)-ADX 71743
Chemical Name: 6-(2,4-Dimethylphenyl)-2-ethyl-6,7-dihydro-4(5H)-benzoxazolone
Purity: ≥98%
Biological Activity
(±)-ADX 71743 is a negative allosteric modulator at mGlu7 (IC50 = 300 nM). Blocks high frequency-induced LTP at SC-CA1 synapses in hippocampal slices in vitro. Increases evoked excitatory postsynaptic currents (eEPSCs) in mice. Brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SC-CA1 synapses in the hippocampus.
Klar et al.
J.Neurosci., 2015;35:7600 -
Phasic and tonic mGlu7 receptor activity modulates the thalamocortical network.
Tassin et al.
Front Neural Circuits, 2016;10:31
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Citation for (±)-ADX 71743
The citations listed below are publications that use Tocris products. Selected citations for (±)-ADX 71743 include:
1 Citation: Showing 1 - 1
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Subsynaptic mobility of presynaptic mGluR types is differentially regulated by intra- and extracellular interactions.
Authors: Harold D Et al.
Mol Biol Cell 2022;33:ar66
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