Home / mAChR M2 Antagonists / AF-DX 384

AF-DX 384

Catalog #: 1345 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1345/10
1345/50
AF-DX 384 | CAS No. 118290-26-9 | mAChR M2 Antagonists
1 Image
Description: Potent M2/M4 antagonist

Chemical Name: N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide

Purity: ≥98%

Product Details
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AF-DX 384 is a potent M2/M4 selective antagonist (pKi values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human M2, M4, M1, M3 and M5 receptors respectively).

Technical Data

M.Wt:
478.64
Formula:
C27H38N6O2
Solubility:
Soluble to 50 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
118290-26-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Regional changes in the cholinergic system in mice lacking monoamine A.
    Grailhe et al.
    Brain Res.Bull., 2009;78:283
  2. AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section autoradiography.
    Dopke et al.
    J.Pharmacol.Exp.Ther., 1995;274:562
  3. Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors.
    Miller et al.
    J.Pharmacol.Exp.Ther., 1991;259:601

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for AF-DX 384

There are currently no reviews for this product. Be the first to review AF-DX 384 and earn rewards!

Have you used AF-DX 384?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.