AG 490

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages.
   Koscso B, Csoka B, Kokai E, Nemeth Z, Pacher P, Virag L, Leibovich S, Hasko G
   J Leukoc Biol, 2013;94(6):1309-15.
3. Methotrexate Combined with 4-Hydroperoxycyclophosphamide Downregulates Multidrug-Resistance P-Glycoprotein Expression Induced by Methotrexate in Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the JAK2/STAT3 Pathway
   K Qin, K Chen, W Zhao, X Zhao, J Luo, Q Wang, C Gao, X Li, C Wang
   J Immunol Res, 2018;2018(0):3619320.
4. PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy
   
   EMBO Mol Med, 2016;0(0):.
5. The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude mice.
   Abe et al.
   Int.Immunopharmacol., 2009;9:870
6. Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
   Gazit et al.
   J.Med.Chem., 1991;34:1896
7. Inhbition of acute lymphoblastic leukaemia by a JAK-2 inhibitor.
   Meydan et al.
   Nature, 1996;379:645
8. JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response.
   Wang et al.
   J.Immunol., 1999;162:3897

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