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AI-3

Catalog #: 5145 Datasheet / COA / SDS

Discontinued Product

5145 has been discontinued.
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AI-3 | CAS No. 882288-28-0 | Nrf2 Activators
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Description: ARE activator; induces Nrf2-ARE-dependent transcription

Chemical Name: 1-Chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-benzo[c]thiophen-4(5H)-one

Purity: ≥98%

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Biological Activity

AI-3 is an antioxidant response element (ARE) activator; disrupts Nrf2/Keap1 and Keap1/Cul3 interactions and stabilizes Nrf2. Activates ARE in an Nrf2 and PI 3-kinase dependent manner. Induces cytoprotective gene expression in vitro and in vivo.

Technical Data

M.Wt:
292.8
Formula:
C11H13ClO3S2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
882288-28-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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