Ailanthone

Catalog #: 6161 Datasheet / COA / SDS

Discontinued Product

6161 has been discontinued.
View all Androgen Receptor Antagonists products.
Ailanthone | CAS No. 981-15-7 | Androgen Receptor Antagonists
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Description: Potent inhibitor of androgen receptor (AR)

Chemical Name: (1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione

Purity: ≥98%

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Biological Activity

Ailanthone is a potent androgen receptor (AR) inhibitor (IC50 = 69 nM). Disrupts the AR-chaperone complex by binding p23 and blocking AR interaction with HSP90 causing UPS degradation of AR. Inhibits Huh7 cancer cell growth via G0/G1 cell cycle arrest and apoptosis in vitro and in vivo. Inhibits growth and metastasis of certain prostate cancer cell lines. Orally bioavailable.

Technical Data

M.Wt:
376.4
Formula:
C20H24O7
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
981-15-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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