AK 7
Chemical Name: N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]benzamide
Purity: ≥98%
Biological Activity
AK 7 is a selective SIRT2 inhibitor (IC50 = 15.5 μM); displays no effect on SIRT1 or SIRT3. Decreases neuronal cholesterol levels; improves motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The sirtuin inhibitor AK-7 is neuroprotective in Huntington's disease mouse models.
Chopra et al.
Cell Rep., 2012;2:1492 -
A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase.
Taylor et al.
ACS Chem.Biol., 2011;6:540
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Citation for AK 7
The citations listed below are publications that use Tocris products. Selected citations for AK 7 include:
1 Citation: Showing 1 - 1
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SIRT2-PFKP interaction dysregulates phagocytosis in macrophages with acute ethanol-exposure.
Authors: Sanjoy Et al.
Front Immunol 2023;13:1079962
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