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Alda 1

Catalog #: 4005
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4005/10
4005/50
Alda 1 | CAS No. 349438-38-6 | Dehydrogenase Activators
1 Image
Description: ALDH2 activator; cardioprotective

Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide

Purity: ≥99%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Alda 1 is an activator of aldehyde dehydrogenase 2 (ALDH2). Increases activity of wild-type ALDH2*1 and variant ALDH2*2 (by ~2-fold and 11-fold respectively). Capable of partly restoring mutant ALDH2*2 activity; protective against cardiac ischemia.

Technical Data

M.Wt:
324.16
Formula:
C15H11Cl2NO3
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
349438-38-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Impaired cardiac SIRT1 activity by carbonyl stress contributes to aging-related ischemic intolerance.
    Gu, Chunhu, Xing, Yuan, Jiang, Li, Chen, Mai, Xu, Ming, Yin, Yue, Li, Chen, Yang, Zheng, Yu, Lu, Ma, Heng
    PLoS ONE, 2013;8(9):e74050.
  2. An activator of mutant and wildtype aldehyde dehydrogenase reduces ischemic damage to the heart.
    Chen et al.
    Science, 2008;321:1493
  3. Characterization of the East Asian variant of aldehyde dehydrogenase-2. Bioactivation of nitrogly. and effects of alda-1.
    Beretta et al.
    J.Biol.Chem., 2010;285:943

Product Datasheets

Reconstitution Calculator
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Reconstitution Calculator

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Citations for Alda 1

The citations listed below are publications that use Tocris products. Selected citations for Alda 1 include:

2 Citations: Showing 1 - 2

  1. Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol-impaired TFEB and liver injury in mice.
    Authors: Ling Et al.
    Alcohol Clin Exp Res  2021;45:1950-1964
  2. Protection of retinal function and morphology in MNU-induced retinitis pigmentosa rats by ALDH2: an in-vivo study.
    Authors: Tao Et al.
    BMC Ophthalmol  2020;20:55

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