Home / Protein Tyrosine Phosphatase Inhibitors / Alexidine dihydrochloride

Alexidine dihydrochloride

Catalog #: 3979
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3979/50
Alexidine dihydrochloride | CAS No. 1715-30-6 | Protein Tyrosine Phosphatase Inhibitors
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Description: Selective inhibitor of PTPMT1

Chemical Name: N,N''-Bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide dihydrochloride

Product Details
Citations (1)
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Biological Activity

Alexidine dihydrochloride is a selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC50 = 1.08 μM in vitro). Stimulates increased insulin secretion by β-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells. Also preserves functional hematopoietic stem cells ex vivo.

Technical Data

M.Wt:
581.71
Formula:
C26H56N10.2HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Desiccate at -20°C
CAS No:
1715-30-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Alexidine dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Alexidine dihydrochloride include:

1 Citation: Showing 1 - 1

  1. Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death.
    Authors: Niemi Et al.
    PLoS One  2013;8:e53803

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