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α-Methyl-5-hydroxytryptamine maleate

Catalog #: 0557
4 Citations Datasheet / COA / SDS

Discontinued Product

0557 has been discontinued.
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α-Methyl-5-hydroxytryptamine maleate | CAS No. 97469-12-0 | 5-HT2B Receptor Agonists
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Description: 5-HT2B agonist

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

5-HT2B receptor selective agonist with pKi values of 8.4, 6.1 and 7.3 at 5-HT2B, 5-HT2A and 5-HT2C receptors respectively.

Technical Data

M.Wt:
306.32
Formula:
C11H14N2O.C4H4O4
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
97469-12-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pericytes impair capillary blood flow and motor function after chronic spinal cord injury
    Y Li, AM Lucas-Osma, S Black, MV Bandet, MJ Stephens, R Vavrek, L Sanelli, KK Fenrich, AF Di Narzo, S Dracheva, IR Winship, K Fouad, DJ Bennett
    Nat. Med., 2017;0(0):.
  2. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  3. 5-HT2 receptor subtypes: a family re-united?
    Baxter et al.
    TiPS, 1995;16:105
  4. Identification of serotonin M-receptor sub-types and their specific blockade by a new class of drugs.
    Richardson et al.
    Nature, 1985;316:126
  5. 5-Hydroxytryptamine3 receptors mediate tachycardia in conscious instrumented dogs.
    Wilson et al.
    J.Pharmacol.Exp.Ther., 1990;252:683

Product Datasheets

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Citations for α-Methyl-5-hydroxytryptamine maleate

The citations listed below are publications that use Tocris products. Selected citations for α-Methyl-5-hydroxytryptamine maleate include:

4 Citations: Showing 1 - 4

  1. Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice.
    Authors: Nguyen Et al.
    Korean J Physiol Pharmacol  2019;23:271
  2. Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons.
    Authors: Athilingam Et al.
    Elife  2017;6
  3. Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster.
    Authors: Majeed Et al.
    Neural Plast  2016;2016:7291438
  4. Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling.
    Authors: Coulon Et al.
    Front Cell Neurosci  2011;4:132

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