Amyloid β-peptide (1-42) (rat)
Purity: ≥95%
Biological Activity
Amyloid β-peptide (1-42) (rat) is a rat form of the predominant amyloid β-peptide found in plaques associated with Alzheimer's disease. Leads to a large shift in the bax/bcl-2 ratio in favour of pro-apoptotic bax. Neurotoxic.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Amyloid β-protein induces the cerebrovascular cellular pathology of Alzheimer's disease and related disorders.
Van Nostrand et al.
Ann.N.Y.Acad.Sci., 1996;777:297 -
Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.
Glenner and Wong
Biochem.Biophys.Res.Comm., 1984;120:885 -
Alzheimer's amyloid β-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: An intriguing role for methionine 35.
Clementi et al.
Biochem.Biophys.Res.Comm., 2006;342:206
Product Datasheets
Citation for Amyloid β-peptide (1-42) (rat)
The citations listed below are publications that use Tocris products. Selected citations for Amyloid β-peptide (1-42) (rat) include:
1 Citation: Showing 1 - 1
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Partial Amelioration of Synaptic and Cognitive Deficits by Inhibiting Cofilin Dephosphorylation in an Animal Model of Alzheimer's Disease
Authors: Yulei Et al.
Journal of Alzheimer's Disease 2016;53:1419
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