ANA 12
Chemical Name: N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide
Purity: ≥98%
Biological Activity
ANA 12 is a TrkB receptor antagonist. Demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6 nM and 41.1 μM for the high and low affinity sites respectively). Displays no effect on TrkA and TrkC in an assay of neurite outgrowth. Demonstrates antidepressant properties. Also exhibits anti-seizure effects in an ischemia-induced neonatal seizure model by blocking down-regulation of KCC2.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Dose-dependent reversal of KCC2 hypofunction and phenobarbital-resistant neonatal seizures by ANA12.
Carter et al.
Sci.Rep., 2018;8:11987 -
Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice.
Cazorla et al.
J.Clin.Invest., 2011;121:1846
Product Datasheets
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Citations for ANA 12
The citations listed below are publications that use Tocris products. Selected citations for ANA 12 include:
15 Citations: Showing 1 - 10
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Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia.
Authors: Vicente Et al.
Int J Mol Sci 2022;23
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Cleaved PINK1 induces neuronal plasticity through PKA-mediated BDNF functional regulation.
Authors: Marisela Et al.
J Neurosci Res 2021;99:2134-2155
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Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement.
Authors: Nury Et al.
Sci Adv 2020;6:eaaz9691
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Prolonged Use of NMDAR Antagonist Develops Analgesic Tolerance in Neuropathic Pain via Nitric Oxide Reduction-Induced GABAergic Disinhibition.
Authors: Jun Et al.
Neurotherapeutics 2020;17:1016-1030
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Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain.
Authors: Zhou Et al.
Cell Rep 2019;27:3844
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Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons.
Authors: Livingstone Et al.
Front Mol Neurosci 2019;12:198
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Parvalbumin-Interneuron Output Synapses Show Spike-Timing-Dependent Plasticity that Contributes to Auditory Map Remodeling.
Authors: Bernhard Et al.
Neuron 2018;99:720-735.e6
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7,8,3'-Trihydroxyflavone ameliorate oxidative stress in vivo and promotes neurite regeneration in vitro in rat retinal ganglion cells.
Authors: Han Et al.
Eur.J.Pharmacol. 2018;823:283
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The 3' UTRs of Brain-Derived Neurotrophic Factor Transcripts Differentially Regulate the Dendritic Arbor.
Authors: O'Neill Et al.
Front Cell Neurosci 2018;12:60
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Minocycline promotes posthemorrhagic neurogenesis via M2 microglia polarization via upregulation of the TrkB/BDNF pathway in rats.
Authors: Hang Et al.
J Neurophysiol 2018;120:1307-1317
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LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.
Authors: Hashimotodani Et al.
Neuron 2017;95:928
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Subthalamic Nucleus Deep Brain Stimulation Employs trkB Signaling for Neuroprotection and Functional Restoration.
Authors: Fischer Et al.
J Neurosci 2017;37:6786
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Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas
Authors: Shamblott Et al.
Cell Communication and Signaling 2016;14:23
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Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2(TRKB) signaling in the adult human exocrine pancreas.
Authors: Shamblott Et al.
Cell Communication and Signaling 2016;14:23
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High-Speed imaging reveals opposing effects of chronic stress and antidepressants on neuronal activity propagation through the hippocampal trisynaptic circuit.
Authors: Stepan Et al.
Front Neural Circuits 2015;9:70
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