Angiotensin A

Biological Activity

Angiotensin A is a potent endogenous vasoconstrictor peptide; derivative of angiotensin (Ang) II. Elicits pressor and renal vasoconstrictor effects in rodents via the AT₁ receptor; inhibited by Candesartan (Cat. No. 4791) but not by AT₂ receptor ligands in vivo. Displays a similar affinity for AT₁ and AT₂ receptors as angiotensin II in vitro (K_i values are 1.6 and 2.3 nM at AT₁ and AT₂ receptors); also increases inositol phosphate accumulation with a similar potency to Ang II (EC₅₀ = 6.7 nM).

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Alamandine: a new member of the angiotensin family.
   Villela et al.
   Curr.Opin.Nephrol.Hypertens., 2014;23:130
2. Pressor and renal hemodynamic effects of the novel angiotensin A peptide are angiotensin II type 1A receptor dependent.
   Yang et al.
   Hypertension, 2011;57:956
3. Cardiovascular effects of angiotensin A: A novel peptide of the renin-angiotensin system.
   Coutinho et al.
   J.Renin Angiotensin Aldosterone Syst., 2013;15:480

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