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AP C5

Catalog #: 6626 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6626/50
6626/10
AP C5 | CAS No. 2234272-10-5 | Protein Kinase G Inhibitors
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Description: Potent and selective PKG2 inhibitor

Chemical Name: 4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine

Purity: ≥98%

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Biological Activity

AP C5 is a potent and selective protein kinase G type II (PKG2) inhibitor (pIC50 = 7.2). Displays >20-fold selectivity for PKG2 over PKG1 and PKA (pIC50 values are 4.6 and 4.8 for PKG1 and PKA, respectively). Blocks 8-pCPT-cGMP-dependent VASP phosphorylation in intestinal organoids. Also attenuates toxin-stimulated anion secretory responses in mouse intestinal tissue.

Technical Data

M.Wt:
275.31
Formula:
C16H13N5
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2234272-10-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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