Home / Ubiquitin Ligase (E3) Inhibitors / Apcin

Apcin

Catalog #: 5747
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5747/10
5747/50
Apcin | CAS No. 300815-04-7 | Ubiquitin Ligase (E3) Inhibitors
1 Image
Description: Cdc20 inhibitor; inhibits Cdc20-substrate interaction

Chemical Name: 3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide

Purity: ≥98%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Apcin is a Cdc20 inhibitor; inhibits Cdc20-substrate interaction. Blocks substrate-mediated Cdc20 loading onto the anaphase-promoting complex (APC). Inhibits APC-dependent ubiquitylation. Prolongs mitotic duration in RPE1 cells in combination with proTAME (prodrug of TAME (Cat.No. 4506)) in vitro.

Technical Data

M.Wt:
438.65
Formula:
C13H14Cl3N7O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
300815-04-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
    Sackton KL, Dimova N, Zeng X et al.
    Nature.
  2. Targeting Cdc20 as a novel cancer therapeutic strategy.
    Wang et al.
    Pharmacol.Ther., 2015;151:141
  3. Hyperphosphorylation of CDH1 in glioblastoma cancer stem cells attenuates APC/CCDH1 activity and pharmacological inhibition of APC/CCDH1/CDC20 compromises viability
    K De, TM Grubb, AA Zalenski, KE Pfaff, D Pal, S Majumder, MK Summers, M Venere
    Mol. Cancer Res., 2019;0(0):.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Apcin

The citations listed below are publications that use Tocris products. Selected citations for Apcin include:

5 Citations: Showing 1 - 5

  1. AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation.
    Authors: Venturina Et al.
    Life Sci Alliance  2023;6
  2. Kinetochore deterioration concommitant with centromere weakening during aging in mouse oocyte meiosis-I.
    Authors: Lin Et al.
    FASEB J  2023;37:e22922
  3. Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit.
    Authors: Shabaz Et al.
    Elife  2020;9
  4. Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk.
    Authors: Afonso Et al.
    Elife  2019;8
  5. Tetraploidy causes chromosomal instability in acentriolar mouse embryos.
    Authors: Greg Et al.
    Nat Commun  2019;10:4834

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Apcin

There are currently no reviews for this product. Be the first to review Apcin and earn rewards!

Have you used Apcin?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.