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TAME hydrochloride

Catalog #: 4506
1 Citation Datasheet / COA / SDS

Discontinued Product

4506 has been discontinued.
View all Ubiquitin Ligase (E3) Inhibitors products.
TAME hydrochloride | CAS No. 1784-03-8 | Ubiquitin Ligase (E3) Inhibitors
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Description: Ubiquitin ligase APC/C inhibitor; promotes Cdc20 autoubiquitination

Chemical Name: N2-[(4-Methylphenyl)sulfonyl]-L-arginine methyl ester hydrochloride

Purity: ≥99%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TAME hydrochloride is a competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. Inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 = 12 μM) and blocks cyclin degradation in interphase extract.

Technical Data

M.Wt:
378.87
Formula:
C14H22N4O4S.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
1784-03-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for TAME hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for TAME hydrochloride include:

1 Citation: Showing 1 - 1

  1. KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms.
    Authors: Coles Et al.
    PLoS Genet  2015;11:e1005525

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