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Aprotinin

Catalog #: 4139
4 Citations 2 Reviews Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4139/10
Aprotinin
1 Image
Description: Competitive serine protease inhibitor
Product Details
Citations (4)
Reviews (2)
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Aprotinin is a competitive serine protease inhibitor. Reversibly binds to and blocks the enzymatic active site. Inhibits a range of serine proteases including trypsin, chymotrypsin, kallikrein and plasmin. Inhibits cytopathogenic effect of SARS-CoV-2 and double-stranded RNA formation in SARS-CoV-2-infected cells.

This product is from Bovine Lung.

Technical Data

M.Wt:
6511.48
Formula:
C284H432N84O79S7
Sequence:
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA

(Modifications: Disulfide bridges: 5-55, 14-38, 30-51)

Solubility:
Soluble to 4 mg/ml in water
Storage:
Store at +4°C
CAS No:
9087-70-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:
  • from Bovine Lung

Background References

  1. Elastase and tryptase govern TNFa-mediated production of active chemerin by adipocytes.
    Parlee et al.
    PLoS ONE, 2012;7:e51072
  2. Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature.
    Reichel et al.
    PLoS ONE, 2011;6:e17229
  3. SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles.
    Bojkova et al.
    BioRxiv - Paper not yet peer reviewed., 2020;
  4. bFGF blockade reduces intraplaque angiogenesis and macrophage infiltration in atherosclerotic vein graft lesions in ApoE3*Leiden mice
    L Parma, HAB Peters, TJ Sluiter, KH Simons, P Lazzari, MR de Vries, PHA Quax
    Sci Rep, 2020;10(1):15968.

Product Datasheets

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Reconstitution Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Aprotinin

The citations listed below are publications that use Tocris products. Selected citations for Aprotinin include:

4 Citations: Showing 1 - 4

  1. Induction of Apoptosis and Decrease of Autophagy in Colon Cancer Cells by an Extract of Lyophilized Mango Pulp.
    Authors: María Elena Et al.
    Int J Environ Res Public Health  2023;20
  2. Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness.
    Authors: Yan Et al.
    Cell Metab  2022;34:90-105.e7
  3. Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation.
    Authors: Berg Et al.
    Cell Rep  2019;27:2837
  4. Poly(ethylene glycol)-crosslinked gelatin hydrogel substrates with conjugated bioactive peptides influence endothelial cell behavior.
    Authors: Simon C Et al.
    Biomaterials  2019;201:99-112

FAQs

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Reviews for Aprotinin

Average Rating: 4.5 (Based on 2 Reviews)

5 Star
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Aprotonin 10mg
By Anonymous on 11/11/2024
Species: Human

Used to make a buffer for an ELISA kit (DYC1047-2). Worked well.

surgery research
By Anonymous on 05/30/2018

Used in surgery research. Reduces inflammation and bleeding. Reasonably priced. You can dilute this aprotinin depending on your intended use, though dilute solutions are typically less stable. Will definitely purchase from R&D again.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.