Argatroban
Chemical Name: (2R,4R)-1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
Purity: ≥99%
Biological Activity
Argatroban is a potent inhibitor of thrombin mediated fibrinogen cleavage (Ki = 19 nM). Competitive inhibitor of thrombin-induced platelet activation and clotting. Shown to exhibit antithrombotic activity in animal models.This compound is a mixture of 2 diastereomers (approximate ratio 65/35).
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
- This compound is a mixture of 2 diastereomers (approximate ratio 65/35)
Background References
-
Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-1-arginyl)]-2-piperidinecarboxylic acid.
Kikumoto et al.
Biochemistry, 1984;23:85 -
Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition.
Jang et al.
Circulation, 1990;81:219 -
Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator.
Fitzgerald and Fitzgerald
Proc.Natl.Acad.Sci.USA, 1989;86:7585
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