AS 1892802
Chemical Name: N-[(1S)-2-Hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea
Purity: ≥99%
Biological Activity
AS 1892802 is a potent, ATP-competitive ROCK inhibitor (IC50 values are 52, 57 and 122 nM for human ROCK2, rat ROCK2 and human ROCK1 respectively by ELISA); also inhibits PKAC-α and PRKX (IC50 values are 200 and 325 nM respectively). Exhibits analgesic effects in rat models of inflammatory (AIA) and noninflammatory (MIA) arthritic pain. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors.
Li et al.
J.Med.Chem., 2012;55:2474 -
Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis.
Yoshimi et al.
J.Pharmacol.Exp.Ther., 2010;334:955
Product Datasheets
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Citation for AS 1892802
The citations listed below are publications that use Tocris products. Selected citations for AS 1892802 include:
1 Citation: Showing 1 - 1
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Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators.
Authors: Alexandra E Et al.
Cell Chem Biol 2017;24:858-869.e5
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