AS 2444697

Name: AS 2444697
Brand: Tocris Bioscience
SKU: 5430
Rating: 4.7 (3 reviews)

Catalog #: 5430
1 Citation 3 Reviews Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
5430/10
5430/50

AS 2444697 | CAS No. 1287665-60-4 | IRAK Inhibitors

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Description: Potent and selective IRAK4 inhibitor

Chemical Name: N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride

Purity: ≥98%

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Product Details

Citations (1)

Reviews (3)

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AS 2444697 is a potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC₅₀ = 21 nM). Displays 30-fold selectivity for IRAK4 over IRAK1. Inhibits LPS-induced TNF-α and IL-6 production in PBMCs in vitro. Renoprotective and anti-inflammatory in a rodent model of chronic kidney disease.

Technical Data

M.Wt:

432.86

Formula:

C₁₉H₂₀N₆O₄.HCl

Solubility:

Soluble to 20 mM in DMSO with gentle warming

Purity:

≥98%

Storage:

Desiccate at RT

CAS No:

1287665-60-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders.
Chaudhary
J.Med.Chem., 2015;58:96
Renoprotective effects of novel interleukin-1 receptor-associated kinase 4 inhibitor AS2444697 through anti-inflammatory action in 5/6 nephrectomized rats.
Kondo et al.
Naunyn Schmiedebergs Arch.Pharmacol., 2014;387:909
Blocking innate immunity to slow the progression of chronic kidney disease.
Schmaderer and Heemann
Naunyn Schmiedebergs Arch.Pharmacol., 2014;387:905

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Citation for AS 2444697

The citations listed below are publications that use Tocris products. Selected citations for AS 2444697 include:

1 Citation: Showing 1 - 1

Tumor-Stroma IL1β-IRAK4 Feedforward Circuitry Drives Tumor Fibrosis, Chemoresistance, and Poor Prognosis in Pancreatic Cancer.
Authors: Zhang Et al.
Cancer Res 2018;78:1700

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Reviews for AS 2444697

Average Rating: 4.7 (Based on 3 Reviews)

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In vivo

By Anonymous on 08/07/2021

Species: Mouse

In vivo study

In vitro study

By Anonymous on 02/28/2021

Species: Human

In vitro time/conc treatment

oral admingistration

By Anonymous on 11/29/2018

0.5 % methylcellulose solution

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