ASP 9521

Name: ASP 9521
Brand: Tocris Bioscience
SKU: 6084
Price: 79 USD

Catalog #: 6084 Datasheet / COA / SDS

Discontinued Product

6084 has been discontinued.

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ASP 9521 | CAS No. 1126084-37-4 | Dehydrogenase Inhibitors

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Description: Potent 17β-hydroxysteroid dehydrogenase type 5 inhibitor;orally bioavailable

Chemical Name: [4-(2-Hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)methanone

Purity: ≥98%

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Product Details

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Biological Activity

ASP 9521 is a potent 17β-hydroxysteroid dehydrogenase type 5 inhibitor (IC₅₀ = 11 - 49 nM). Suppresses androstenedione-dependent protein-specific antigen (PSA) production and cell proliferation in LNCaP cells in vitro. Orally bioavailable.

Technical Data

M.Wt:

330.42

Formula:

C₁₉H₂₆N₂O₃

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

1126084-37-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

In vitro and in vivo characterisation of ASP9521: a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3).
Kikuchi et al.
Invest.New Drugs, 2014;32:860

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