AT 7867
Chemical Name: 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine hydrochloride
Purity: ≥98%
Biological Activity
AT 7867 is a potent pan-Akt (protein kinase B) and protein kinase A (PKA) inhibitor (IC50 values are 32, 17, 47 and 20 nM for Akt1, Akt2, Akt3 and PKA, respectively). Also inhibits p70-S6 kinase (p70S6K, IC50 = 85 nM). Inhibits Akt signaling and proliferation of multiple human cancer cell lines, including breast, prostate and colon. Promotes proliferation of iPSC-derived PDX1+ pancreatic progenitor cells (PPCs).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth.
Grimshaw et al.
Mol.Cancer Ther., 2010;9:1100 -
Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells.
Kimura et al.
Stem Cell Res., 2017;24:61
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