ATI 2341

Catalog #: 5795 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
5795/1

1 Image

Description: CXCR4 allosteric agonist

Purity: ≥95%

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Biological Activity

ATI 2341 is a CXCR4 allosteric agonist (EC₅₀ = 194 nM). Induces chemotaxis in CXCR4-expressing cells in vitro. Mobilizes polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) from bone marrow niche in vivo. Exhibits biased signaling towards G_i proteins over G₁₃ and β-arrestin.

Technical Data

M.Wt:

2256.82

Formula:

C₁₀₄H₁₇₈N₂₆O₂₅S₂

Sequence:

MGYQKKLRSMTDKYRL

(Modification: Met-1 = N-terminal Palmitoyl)

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

1337878-62-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.
Tchernychev et al.
Proc.Natl.Acad.Sci.U.S.A., 2010;107:22255
Studying the binding interactions of allosteric agonists and antagonists of the CXCR4 receptor.
Planesas et al.
J.Mol.Graph Model., 2015;60:1
Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein.
Quoyer et al.
Proc.Natl.Acad.Sci.U.S.A., 2013;110:E5088

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