Autophinib
Chemical Name: 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine
Purity: ≥98%
Biological Activity
Autophinib is a potent VPS34 (class III PI 3-kinase) inhibitor (IC50 = 19 nM). Inhibits starvation- and Rapamycin-induced autophagy (IC50 values = 40 and 90 nM, respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification and further development of potent TBK1 inhibitors.
Richters et al.
ACS Chem Biol., 2015;10:289 -
Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34.
Robke et al.
Angew.Chem.Int.Ed.Engl., 2017;56:8153
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Citation for Autophinib
The citations listed below are publications that use Tocris products. Selected citations for Autophinib include:
1 Citation: Showing 1 - 1
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TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells.
Authors: Dominique Et al.
Biochem J 2021;478:3145-3155
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