Auxin
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Description: Chemical dimerizer used in auxin-inducible degron (AID) system; phytohormone
Chemical Name: 1H-Indole-3-acetic acid
Purity: ≥98%
Biological Activity
Auxin is a chemical dimerizer used in auxin-inducible degron (AID) systems. Induces degradation of a target protein tagged with the auxin-receptor F-box protein Tir1 E3 ligase AID in human colorectral cancer and mouse ES cells or tagged with AFB2 in A431 cells. Endogenous plant hormone.Technical Data
M.Wt:
175.18
Formula:
C10H9NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
87-51-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
An auxin-based degron system for the rapid depletion of proteins in nonplant cells.
Nishimura et al.
Nat.Methods, 2009;6:917 -
Rapid protein depletion in human cells by auxin-inducible degron tagging with short homology donors.
Natsume et al.
Cell Rep., 2016;15:210 -
An efficient auxin-inducible degron system with low basal degradation in human cells.
Li et al.
Nat.Methods., 2019;16:866
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