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AX 15836

Catalog #: 5843
1 Citation Datasheet / COA / SDS
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5843/10
AX 15836 | CAS No. 2035509-96-5 | ERK Inhibitors
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Description: Potent and selective ERK5 inhibitor

Chemical Name: 5,11-Dihydro-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-methyl,11-(methylsulfonyl)-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AX 15836 is a potent and selective ERK5 inhibitor (IC50 = 8 nM). Exhibits >1,000-fold selectivity for ERK5 over a panel of over 200 kinases. Also exhibits selectivity over bromodomain BRD4 (Kd = 3,600 nM). Increases vomocytosis in human macrophages in vitro, as well as in an in vivo zebrafish model of cryptococcal disease, reducing spread of infection.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of AX15836 is reviewed on the chemical probes website.

Technical Data

M.Wt:
648.78
Formula:
C32H40N8O5S
Solubility:
Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2035509-96-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. ERK5 kinase activity is dispensable for cellular immune response and proliferation.
    Lin et al.
    Proc.Natl.Acad.Sci.U.S.A., 2016;113:11865

Product Datasheets

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Citation for AX 15836

The citations listed below are publications that use Tocris products. Selected citations for AX 15836 include:

1 Citation: Showing 1 - 1

  1. CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci.
    Authors: Ignacio Et al.
    Cell Rep  2020;33:108545

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