AY 77
Discontinued Product
7033 has been discontinued.
View all Protease-Activated Receptor Agonists products.
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Description: Potent PAR2 biased agonist; exhibits bias for Ca2+ signaling
Purity: ≥95%
Biological Activity
AY 77 is a potent PAR2 biased agonist. AY 77 exhibits bias for Ca2+ over ERK1/2 signaling (EC50 values are 40 nM for Ca2+ release versus 2 μM for ERK1/2 phosphorylation). Shows selectivity for PAR2 over PAR1. Promotes migration of human breast cancer cells in vitro.Technical Data
M.Wt:
404.5
Formula:
C21H32N4O4
Sequence:
XX
(Modifications: X-1 = 5-Isoxazolylcarbonyl-Cha, X-2 = Chg, C-terminal amide)
Solubility:
Soluble to 1 mg/ml in ethanol
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
1835734-92-3
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
-
Biased signaling by agonists of protease activated receptor 2.
Jiang et al.
ACS Chem.Biol., 2017;12:1217 -
Potent small agonists of protease activated receptor 2.
Yau et al.
ACS Med.Chem.Lett., 2015;7:105
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