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AZ 191

Catalog #: 5232
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5232/50
5232/10
AZ 191 | CAS No. 1594092-37-1 | DYRK Inhibitors
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Description: Potent DYRK1B inhibitor

Chemical Name: N-[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AZ 191 is a potent DYRK1B inhibitor (IC50 values are 17, 88 and 1890 nM for DYRK1B, DYRK1A and DYRK2 respectively). Inhibits DYRK1B-induced Gi phase cell cycle arrest in Panc-1 cells in vitro.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of AZ 191 is reviewed on the chemical probes website.

Technical Data

M.Wt:
429.52
Formula:
C24H27N7O
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1594092-37-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for AZ 191

The citations listed below are publications that use Tocris products. Selected citations for AZ 191 include:

2 Citations: Showing 1 - 2

  1. Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling.
    Authors: Martin Et al.
    Dev Cell  2020;55:629-647.e7
  2. Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer.
    Authors: Blake Et al.
    Sci Signal  2019;12

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