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AZD 5248

Catalog #: 7130 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7130/1
AZD 5248 | CAS No. 1254318-44-9 | Synthetic Cathepsin Inhibitors
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Description: Potent cathepsin C inhibitor

Chemical Name: 4-Amino-N-[(1S)-1-cyano-2-(4'-cyano[1,1'-biphenyl]-4-yl)ethyl]tetrahydro-2H-pyran-4-carboxamide

Purity: ≥98%

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Biological Activity

AZD 5248 is a potent cathepsin C (also known as dipeptidyl peptidase 1, or DPP1) inhibitor (IC50 values are 44 and 67 nM for human and rat, respectively). In vivo, AZD 5248 inhibition of cathepsin C correlates to the reduction of NSP (neutrophil serine protease) activity measured in rat bone marrow and blood. In rats, quantitative whole-body autoradiography studies demonstrate aortic binding of AZ 5248. This compound is orally bioavailable.

Technical Data

M.Wt:
374.44
Formula:
C22H22N4O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1254318-44-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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