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AZD 8055

Catalog #: 7840 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7840/10
7840/50
AZD 8055 | CAS No. 1009298-09-2 | mTOR Inhibitors
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Description: Highly potent and selective mTOR inhibitor

Chemical Name: 5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol

Purity: ≥98%

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Biological Activity

AZD 8055 is a highly potent, selective and ATP-competitive mTOR inhibitor (IC50 = 0.8 nM). Inhibits growth and induces autophagy in a range of cancer cell lines and xenografts, including NSCLC and glioblastoma (IC50 values are 20, 50 and 53 nM in H838, A549 and U87MG cell lines, respectively). Orally bioavailable.

Technical Data

M.Wt:
465.55
Formula:
C25H31N5O4
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1009298-09-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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