Home / DNA, RNA and Protein Synthesis Compounds / Azithromycin

Azithromycin

Catalog #: 3771
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3771/50
Azithromycin | CAS No. 83905-01-5 | DNA, RNA and Protein Synthesis Compounds
1 Image
Description: Antibiotic; inhibits 50S ribosomal subunit formation and elongation at transpeptidation
Alternative Names: CP 62993

Chemical Name: 13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one

Purity: ≥99%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Azithromycin is a macrolide antibiotic. Inhibits 50S ribosomal subunit formation and elongation at transpeptidation step in gram-positive and gram-negative organisms. Orally active with improved pharmacokinetics over erythromycin in mouse models. Inhibits autophagy. Predicted to disrupt binding of SARS-CoV-2 spike protein to ACE2.

Technical Data

M.Wt:
748.98
Formula:
C38H72N2O12
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
83905-01-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
    Galluzzi et al.
    Nat.Rev.Drug.Discov., 2017;
  2. Macrolide antibiotics inhibit 50S ribosomal subunit assembly in Bacillus subtilis and Staphylococcus aureas.
    Champney and Burdine
    Antimicrob.Agents Chemother., 1995;39:2141
  3. Pharmacokinetic and in vivo studies with azithro. (CP-62,993), a new macrolide with extended half-life and excellent tissue distribution.
    Girard et al.
    Antimicrob.Agents Chemother., 1987;31:1948
  4. Spectrum and mode of action of azithro. (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms.
    Retsema et al.
    Antimicrob.Agents Chemother., 1987;31:1939
  5. Energetics based modeling of hydroxychloroquine and azithromycin binding to the SARS-CoV-2 spike (S) protein - ACE2 complex.
    Sandeep and McGregor et al.
    ChemRxiv - Paper not yet peer reviewed., 2020;

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Azithromycin

The citations listed below are publications that use Tocris products. Selected citations for Azithromycin include:

3 Citations: Showing 1 - 3

  1. Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent.
    Authors: Groote Et al.
    Front Microbiol  2018;9:2231
  2. Nonoptimal Gene Expression Creates Latent Potential for Antibiotic Resistance.
    Authors: Palmer Et al.
    Mol Biol Evol  2018;35:2669
  3. The antibiotic azithro. is a motilin receptor agonist in human stomach: comparison with erythro.
    Authors: Broad and Sanger
    Br J Pharmacol  2013;168:1859

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Azithromycin

There are currently no reviews for this product. Be the first to review Azithromycin and earn rewards!

Have you used Azithromycin?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.