Bay 11-7085
Chemical Name: (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
Purity: ≥98%
Biological Activity
Bay 11-7085 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation (IC50 ~ 10 μM); leads to decreased NF-κB and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells.
Kwon O, Valdez J, Zhang L, Zhang B, Wei X, Su Q, Ittmann M, Creighton C, Xin L
Nat Commun, 2014;5(0):4416. -
Endothelial Cell Activation is Regulated by Epidermal Growth Factor-Like Domain 7 (Egfl7) during Inflammation
J Biol Chem, 2016;0(0):. -
The transcriptional regulator NAB2 reveals a two-step induction of TRAIL in activated plasmacytoid DCs.
Balzarolo M, Karrich J, Engels S, Blom B, Medema J, Wolkers M
Eur J Immunol, 2012;42(11):3019-27. -
Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-kappaB-dependent phases.
Clark P, Kim R, Pober J, Kluger M
PLoS ONE, 2015;10(3):e0120075. -
An IκBα inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-κB-independent mechanism.
Hu et al.
Cancer Res., 2001;61:6290 -
Nuclear factor κB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis.
Scaife et al.
Cancer Res., 2002;62:6870 -
Novel inhibitors of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo.
Pierce et al.
J.Biol.Chem., 1997;272:21096 -
METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection
N Li, H Hui, B Bray, GM Gonzalez, M Zeller, KG Anderson, R Knight, D Smith, Y Wang, AF Carlin, TM Rana
Cell Reports, 2021;35(6):109091.
Product Datasheets
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Citations for Bay 11-7085
The citations listed below are publications that use Tocris products. Selected citations for Bay 11-7085 include:
6 Citations: Showing 1 - 6
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Six-transmembrane epithelial antigens of the prostate comprise a novel inflammatory nexus in patients with pustular skin disorders.
Authors: Liang Et al.
J Allergy Clin Immunol 2017;139:1217
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Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model.
Authors: Kwon Et al.
J Clin Invest 2016;126:2626
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Tumor Necrosis Factor Disrupts Claudin-5 Endothelial Tight Junction Barriers in Two Distinct NF-κB-Dependent Phases.
Authors: Clark Et al.
PLoS One 2015;10:e0120075
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Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells.
Authors: Kwon Et al.
Nat Commun 2014;5:4416
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Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3.
Authors: Przybyla Et al.
Stem Cells 2013;31:1097
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Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis.
Authors: Hussain Et al.
PLoS One 2012;7:e39945
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