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Bazedoxifene acetate

Catalog #: 5263 Datasheet / COA / SDS

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5263 has been discontinued.
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Bazedoxifene acetate | CAS No. 198481-33-3 | Estrogen and Related Receptor Modulators
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Description: Potent and selective estrogen receptor modulator (SERM)

Chemical Name: 1-[[4-[2-(Hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetate

Purity: ≥98%

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Biological Activity

Bazedoxifene acetate is a potent selective estrogen receptor modulator (SERM) (IC50 values are 26 and 99 nM for ERα and ERβ respectively). Inhibits 17β-estradiol-induced proliferation in MCF-7 cells. Co-treatment with Raloxifene (Cat. No. 2280) completely abolishes raloxifene-induced stimulation of luminal epithelial cells and myometrium.

Technical Data

M.Wt:
530.65
Formula:
C30H34N2O3.C2H4O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
198481-33-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity.
    Komm et al.
    Endocrinology, 2005;146:3999

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