BCH
Chemical Name: 2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid
Biological Activity
BCH is an inhibitor of L-type amino acid transporter LAT1. Suppresses growth and induces apoptosis via activation of caspases in KB, Saos2 and C6 cancer cell lines.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells.
Kim et al.
Biol.Pharm.Bull., 2008;31:1096 -
L-type amino acid transporters in two intestinal epithelial cell lines function as exchangers with neutral amino acids.
Fraga et al.
J.Nutr., 2002;132:733 -
L-type amino acid transporter-1 overexpression and melp. sensitivity in Barrett's adenocarcinoma.
Lin et al.
Neoplasia, 2004;6:74
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Citation for BCH
The citations listed below are publications that use Tocris products. Selected citations for BCH include:
1 Citation: Showing 1 - 1
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Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell cultures.
Authors: Ying Et al.
Br J Pharmacol 2005;146:324-32
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